Complex Disease Genomics

Our research aims to pioneer investigation into the interaction between inherited diseases, mitochondrial dysfunction, and type 2 diabetes from a genetic perspective within the Southern African population. We endeavour to contribute to the diagnosis and early detection of complex genomic diseases by enhancing analysis and diagnostic protocols, while reducing disease severity and improving quality of life for previously diagnosed patients.

Our interdisciplinary approach bridges genetics, anthropology, and medicine to advance equitable, culturally informed healthcare solutions in several key focus areas:

• Genetic Adaptation & Culture: Investigating how traditional diets, healing rituals, and environmental factors influence genetic selection (e.g., lactase persistence, high-altitude adaptation).
• Epigenetics & Social Stressors: Examining how factors like discrimination, stress, and diet alter gene expression, particularly in marginalized communities.
• Genetic Ancestry & Health Disparities: Understanding how historical and genetic factors contribute to differences in health outcomes.
• Cultural Views & Genetic Counseling: Developing culturally sensitive approaches to genetic counseling and patient trust.
• Mitochondrial Genetics & Lifestyle: Studying the interaction between mitochondrial DNA and lifestyle practices in shaping disease risk.
• Indigenous Genomics & Health Equity: Collaborating with Indigenous communities to integrate genetics with traditional health knowledge.
• Ethics in Genetic Research: Addressing issues of consent, data ownership, and equitable collaboration in genetic studies.
• Traditional Medicine & Pharmacogenomics: Exploring genetic factors that influence responses to traditional remedies for personalized medicine.
• Biocultural Aging & Longevity: Investigating how genetics, culture, and social structures contribute to healthy aging.
• Developmental Disorders & Cultural Perceptions: Examining how cultural beliefs influence the diagnosis and treatment of developmental disorders.

Previous Students:

• Craig Engelsman (Hons)
• Muktaar Badrodin (Hons)
• Chantel van Schalkwyk (Hons)